How do genes move in living cells?
The chromatin dynamics is believed to play a key role in controlling the gene expression. However, its quantitative characterization has been elusive mainly due to the complexity in living cells. By combining theory and experiment, we provided unambiguous evidence that the chromatin in early embryos obeys the universal dynamics predicted by the polymer physics (see Figure). Our finding and formulation help researchers quantify the chromatin motion in living cells, thus laying the foundation for future research in this biologically important problem.
Bibliographic information of awarded paper
- Title: Formulation of chromatin mobility as a function of nuclear size during C.elegans embryogenesis using polymer physics theories.
- Authors: Aiya K. Yesbolatova, Ritsuko Arai, *Takahiro Sakaue, and *Akatsuki Kimura.
- Journal Title: Physical Review Letters 128, 178101
- Publication Year: 2022
- DOI: 10.1103/PhysRevLett.128.178101
Department of Genetics YESBOLATOVA, Aiya
My research interests include aging, chromatin mobility, machine learning and its impact on scientific advances. In my free time I teach fundamentals of programming, data analysis and machine learning at Google Developer Student Club SOKENDAI.